Regulation of male gonad development

Across TCGA cell cohorts, RNA activity of the Regulation of male gonad development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGIX, CEMP1, and ACAP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAGIX grouped by Regulation of male gonad development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAGIX →	-1.153	-0.916	<.001	.001	2	6
BLOOD_Lymphoma	CEMP1 →	-1.243	-1.851	.002	<.001	3	5
KIDNEY	ACAP3 →	-1.265	-1.202	.002	.002	3	4
BREAST	RARA →	-1.219	-0.689	.004	.006	2	5
OVARY	ZNF608 →	-1.633	-0.585	.003	.004	3	4
BLOOD_Myeloma	HDAC10 →	-0.663	-1.139	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAGIX by Regulation of male gonad development activity — BREAST

Explore this box plot interactively →