Positive regulation of protein localization to cell surface

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to cell surface pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN6_S388, WDR44_S403, and SAMSN1_S107, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cell surface activity versus SEPTIN6_S388 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN6_S388 →	+0.887	+0.064	<.001	<.001	3	5
CCRCC	WDR44_S403 →	+0.194	+0.047	.001	.001	2	5
UCEC	SAMSN1_S107 →	+0.622	+0.052	<.001	.001	3	4
BRCA	KCNAB2_S9 →	+0.488	+0.023	<.001	.007	3	4
HNSC	PYHIN1 →	+0.832	+0.060	<.001	.001	3	4
LUAD	SPATS2L_S159 →	+0.579	+0.040	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000010 vs SEPTIN6_S388 — GBM

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