Positive regulation of protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MATR3, EPHB2, and SIRT1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cell surface activity versus MATR3 in STOMACH (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MATR3 →	-0.777	-0.164	<.001	<.001	3	10
OESOPHAGUS	EPHB2 →	+1.630	+0.093	.001	.003	3	9
LUNG_NSCLC_LUAD	SIRT1 →	-0.566	-0.080	<.001	.002	3	9
PANCREAS	ABCA7 →	+1.736	+0.147	<.001	<.001	3	9
BREAST	PRKDC →	-1.101	-0.151	<.001	<.001	3	9
BONE	ATP11C →	-1.548	-0.134	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000010 vs MATR3 — STOMACH

Explore this scatter interactively →