Positive regulation of protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLX, CRLF3, and NDRG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cell surface activity versus MLX in BLOOD_Myeloma (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MLX →	+0.620	+0.221	.009	.001	3	6
STOMACH	CRLF3 →	+0.926	+0.091	.009	.004	3	6
LIVER	NDRG1 →	-2.088	-0.118	.008	.002	3	5
LIVER	RAVER2 →	+1.356	+0.141	.002	.003	3	5
UPPER_AERODIGESTIVE_TRACT	ATP13A2 →	-0.851	-0.213	.003	.001	3	5
OVARY	ARL2 →	+1.413	+0.194	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000010 vs MLX — BLOOD_Myeloma

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