Negative regulation of protein localization to cell surface

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to cell surface pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF4G1, NEDD4L, and DNM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to cell surface activity versus EIF4G1 in COAD (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF4G1 →	-0.137	-0.026	.007	<.001	3	5
LSCC	NEDD4L →	+0.379	+0.051	<.001	<.001	3	5
CCRCC	DNM1 →	+0.488	+0.051	<.001	.004	3	5
GBM	DENND4A_S731 →	+0.304	+0.060	.005	.001	3	5
GBM	ECT2_T359 →	-0.647	-0.055	.001	.001	3	5
GBM	EIF3A →	-0.084	-0.036	.008	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000009 vs EIF4G1 — COAD

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