Negative regulation of protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to cell surface pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS11, SLC25A11, and FOXN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS11 grouped by Negative regulation of protein localization to cell surface-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPS11 →	-0.143	-0.673	.002	.002	3	5
BLOOD_Leukemia	SLC25A11 →	-0.262	-1.354	.006	.003	3	4
BLOOD_Leukemia	FOXN1 →	-0.155	-1.203	.001	.001	3	4
LUNG_NSCLC_LUSC	MAPK8IP2 →	+0.313	+1.566	<.001	<.001	3	4
BLOOD_Lymphoma	JAG2 →	+0.366	+1.756	.006	<.001	3	4
BLOOD_Leukemia	TREX2 →	-0.249	-1.262	.006	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS11 by Negative regulation of protein localization to cell surface activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →