Negative regulation of protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTN4, ADAM9, and RRAS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to cell surface activity versus ACTN4 in BONE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ACTN4 →	+1.600	+1.697	.005	<.001	3	8
BREAST	ADAM9 →	+1.675	+1.084	.001	<.001	2	8
LIVER	RRAS →	+3.392	+1.813	<.001	<.001	3	6
BONE	PATZ1 →	-1.392	-1.295	<.001	<.001	3	6
STOMACH	CBX2 →	-2.350	-1.185	.001	.001	3	6
BLOOD_Leukemia	PLSCR4 →	+0.985	+1.084	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000009 vs ACTN4 — BONE

Explore this scatter interactively →