Regulation of protein localization to cell surface

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to cell surface pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPHB2, BIN1, and CLIC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell surface activity versus EPHB2 in PDAC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	EPHB2 →	+0.281	+0.019	<.001	.005	3	5
GBM	BIN1 →	+0.664	+0.070	<.001	<.001	3	5
LUAD	CLIC2 →	+0.280	+0.028	.001	<.001	3	5
GBM	AP2M1 →	+0.302	+0.062	.002	<.001	3	5
LUAD	IQSEC2 →	+0.291	+0.045	<.001	<.001	3	4
GBM	KCNAB2 →	+0.291	+0.037	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000008 vs EPHB2 — PDAC

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