Regulation of protein localization to cell surface

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1A, DACT3, and IRAG1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell surface activity versus MAP1A in HNSC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MAP1A →	+0.893	+0.250	<.001	<.001	3	7
UCEC	DACT3 →	+0.712	+0.254	.008	.001	3	7
GBM	IRAG1 →	+0.938	+0.344	<.001	<.001	3	7
HNSC	PTH1R →	+0.649	+0.232	<.001	<.001	3	7
HNSC	MYL3 →	+1.518	+0.243	<.001	<.001	3	7
HNSC	SYNC →	+0.704	+0.178	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000008 vs MAP1A — HNSC

Explore this scatter interactively →