Regulation of protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCFC2, DTX4, and MOB1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HCFC2 grouped by Regulation of protein localization to cell surface-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	HCFC2 →	-1.264	-1.470	.006	.004	3	5
LIVER	DTX4 →	+2.031	+1.284	.002	.002	3	4
URINARY_TRACT	MOB1B →	-1.035	-2.019	<.001	<.001	3	4
BLOOD_Leukemia	PTK2B →	+1.403	+1.003	<.001	.001	3	4
BLOOD_Leukemia	OTUD1 →	+1.174	+0.888	.006	.009	3	4
BLOOD_Leukemia	PPFIBP2 →	+1.153	+0.784	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HCFC2 by Regulation of protein localization to cell surface activity — LIVER

Explore this box plot interactively →