Regulation of protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cell surface pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP1, ASB6, and SACS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LTBP1 grouped by Regulation of protein localization to cell surface-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LTBP1 →	+0.338	+0.141	.008	.005	3	5
UPPER_AERODIGESTIVE_TRACT	ASB6 →	-0.160	-0.114	.008	.002	2	6
OESOPHAGUS	SACS →	-0.136	-0.128	.004	.002	3	5
LIVER	WDR82 →	-0.282	-0.095	.004	.004	3	4
OVARY	PSMB5 →	-0.409	-0.094	<.001	<.001	3	4
OVARY	IDH3B →	-0.158	-0.075	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LTBP1 by Regulation of protein localization to cell surface activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →