Regulation of protein localization to cell surface

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cell surface pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTFP1, PRRG4, and FAM160A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell surface activity versus MTFP1 in CNS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MTFP1 →	-1.380	-0.269	.001	.001	3	7
LUNG_NSCLC_LUAD	PRRG4 →	+1.270	+0.202	<.001	<.001	3	6
PANCREAS	FAM160A1 →	+1.321	+0.370	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	CUEDC2 →	-0.854	-0.322	.002	<.001	3	5
BLOOD_Leukemia	RECK →	-0.994	-0.081	.001	.002	3	5
OVARY	SH2D3A →	+2.567	+0.371	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000008 vs MTFP1 — CNS

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