Positive regulation of DNA damage checkpoint

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA damage checkpoint pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCAR2, GSR, and PBK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA damage checkpoint activity versus CCAR2 in COAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CCAR2 →	+0.331	+0.043	<.001	<.001	3	8
OV	GSR →	+0.589	+0.049	<.001	<.001	3	6
COAD	PBK →	+0.610	+0.056	<.001	<.001	3	6
OV	PCM1 →	+0.526	+0.062	<.001	<.001	3	6
COAD	PPP2R2A →	+0.450	+0.044	<.001	<.001	3	6
COAD	WRN →	+0.438	+0.054	.003	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000003 vs CCAR2 — COAD

Explore this scatter interactively →