Regulation of DNA damage checkpoint

Across TCGA cell cohorts, RNA activity of the Regulation of DNA damage checkpoint pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AQP12B, B3GNT3, and ELP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AQP12B grouped by Regulation of DNA damage checkpoint-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AQP12B →	+0.241	+0.194	<.001	<.001	3	4
SKIN	B3GNT3 →	-0.296	-0.239	.001	<.001	3	4
BONE	ELP4 →	+0.257	+0.244	.002	.004	2	5
SKIN	OC90 →	-0.135	-0.202	.003	.007	3	3
KIDNEY	PMS2 →	+0.194	+0.191	.002	.003	3	3
KIDNEY	KCNMB2 →	+0.262	+0.255	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AQP12B by Regulation of DNA damage checkpoint activity — SKIN

Explore this box plot interactively →