Response to amino acid starvation

Across TCGA patient cohorts, RNA activity of the Response to amino acid starvation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4, CNRIP1, and FERMT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amino acid starvation activity versus SEPTIN4 in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEPTIN4 →	+0.504	+0.030	.007	.007	3	8
BRCA	CNRIP1 →	+0.607	+0.037	<.001	<.001	3	8
COAD	FERMT2 →	+0.564	+0.023	<.001	<.001	3	8
OV	FRZB →	+0.944	+0.043	<.001	<.001	3	8
OV	ISLR →	+0.618	+0.032	.005	.007	3	8
BRCA	KANK2 →	+0.454	+0.031	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990928 vs SEPTIN4 — OV

Explore this scatter interactively →