Response to amino acid starvation

Across TCGA patient cohorts, RNA activity of the Response to amino acid starvation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS51, VMP1, and CYTOR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amino acid starvation activity versus VPS51 in GBM (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VPS51 →	-0.360	-0.211	.003	<.001	3	3
BRCA	VMP1 →	+0.782	+0.266	<.001	<.001	3	3
BRCA	CYTOR →	+0.326	+0.137	<.001	.009	3	3
UCEC	TRIM26 →	+0.268	+0.164	.008	.006	3	3
OV	DVL1 →	-0.580	-0.153	<.001	.005	2	4
LUAD	ODC1 →	-0.828	-0.290	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990928 vs VPS51 — GBM

Explore this scatter interactively →