Response to amino acid starvation

Across TCGA cell cohorts, RNA activity of the Response to amino acid starvation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MREG, NIPSNAP3A, and H4C3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MREG grouped by Response to amino acid starvation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MREG →	+1.166	+0.448	.005	.001	3	4
SOFT_TISSUE	NIPSNAP3A →	-1.005	-0.351	.007	.002	3	3
SOFT_TISSUE	H4C3 →	+0.877	+0.367	.006	.001	3	3
SOFT_TISSUE	AURKA →	+0.647	+0.331	.009	<.001	3	3
BLOOD_Myeloma	SUN2 →	-1.048	-0.414	.001	<.001	3	3
STOMACH	CARHSP1 →	-0.625	-0.150	.009	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MREG by Response to amino acid starvation activity — SOFT_TISSUE

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