Response to amino acid starvation

Across TCGA cell cohorts, RNA activity of the Response to amino acid starvation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRPEL1, NPM1, and ACAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amino acid starvation activity versus GRPEL1 in LIVER (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GRPEL1 →	+1.160	+0.278	<.001	.001	3	6
PANCREAS	NPM1 →	+1.027	+1.143	.001	.005	3	5
PANCREAS	ACAT1 →	+1.321	+0.744	<.001	.004	3	5
LIVER	NCAPG →	+1.255	+0.310	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TMEM126A →	+1.760	+1.464	.002	.007	3	4
OVARY	PES1 →	+0.628	+0.884	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990928 vs GRPEL1 — LIVER

Explore this scatter interactively →