Double-strand break repair involved in meiotic recombination

Across TCGA patient cohorts, RNA activity of the Double-strand break repair involved in meiotic recombination pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MELK, CENPN, and ERCC6L, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair involved in meiotic recombination activity versus MELK in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MELK →	+1.336	+0.482	<.001	<.001	3	9
BRCA	CENPN →	+0.895	+0.673	<.001	<.001	3	9
LSCC	ERCC6L →	+0.705	+0.892	<.001	<.001	3	9
BRCA	SPAG5 →	+1.180	+0.624	<.001	<.001	3	9
LUAD	KIF4A →	+1.156	+0.492	<.001	<.001	3	9
GBM	KIF18A →	+0.809	+0.373	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990918 vs MELK — GBM

Explore this scatter interactively →