Response to chemokine

Across TCGA patient cohorts, RNA activity of the Response to chemokine pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, TLR8, and LILRA1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to chemokine activity versus CSF2RB in CHOL (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	CSF2RB →	+2.396	+0.075	<.001	<.001	3	34
LAML	TLR8 →	+2.296	+0.065	<.001	<.001	3	34
LAML	LILRA1 →	+1.816	+0.062	<.001	<.001	3	34
LAML	LILRB2 →	+2.358	+0.063	<.001	<.001	3	34
SKCM	GIMAP4 →	+2.086	+0.061	<.001	<.001	3	34
SCLC	MYO1F →	+1.897	+0.114	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990868 vs CSF2RB — CHOL

Explore this scatter interactively →