Response to chemokine

Across TCGA patient cohorts, RNA activity of the Response to chemokine pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, RGS19, and SAMSN1_S107, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to chemokine activity versus RCSD1_S351 in LSCC (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1_S351 →	+0.715	+0.092	<.001	<.001	3	10
UCEC	RGS19 →	+0.522	+0.064	<.001	<.001	3	10
LSCC	SAMSN1_S107 →	+0.804	+0.107	<.001	<.001	3	10
GBM	SAMSN1_S23 →	+0.943	+0.087	<.001	<.001	3	10
LSCC	SASH3 →	+0.561	+0.119	<.001	<.001	3	10
GBM	SEPTIN1 →	+0.985	+0.094	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990868 vs RCSD1_S351 — LSCC

Explore this scatter interactively →