Response to chemokine

Across TCGA patient cohorts, RNA activity of the Response to chemokine pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLA2, FASLG, and CD48, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to chemokine activity versus SLA2 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLA2 →	+0.741	+0.349	.005	.004	3	8
CCRCC	FASLG →	+0.652	+0.467	<.001	.003	3	8
UCEC	CD48 →	+0.691	+0.378	.006	.003	3	7
LSCC	TBX21 →	+0.613	+0.461	<.001	.002	3	7
CCRCC	CRTAM →	+0.694	+0.640	<.001	<.001	3	7
CCRCC	SCIMP →	+0.350	+0.427	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990868 vs SLA2 — BRCA

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