Response to chemokine

Across TCGA cell cohorts, RNA activity of the Response to chemokine pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGTRAP, RHOG, and SLC25A10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGTRAP grouped by Response to chemokine-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AGTRAP →	-2.340	-1.072	<.001	.001	3	5
LUNG_NSCLC_LUSC	RHOG →	-0.966	-1.560	.001	<.001	3	5
LUNG_NSCLC_LUAD	SLC25A10 →	+1.062	+0.882	<.001	<.001	3	5
BLOOD_Leukemia	RAB32 →	-3.350	-1.049	<.001	<.001	3	4
BLOOD_Leukemia	PRMT1 →	+0.695	+0.937	<.001	.002	3	4
BLOOD_Leukemia	NOLC1 →	+0.782	+0.899	.001	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGTRAP by Response to chemokine activity — BLOOD_Leukemia

Explore this box plot interactively →