Vacuolar localization

Across TCGA cell cohorts, RNA activity of the Vacuolar localization pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC21, ZNF513, and NUMBL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC21 grouped by Vacuolar localization-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DNAJC21 →	-1.048	-1.535	<.001	<.001	3	4
CNS	ZNF513 →	+0.953	+1.166	<.001	<.001	3	4
LIVER	NUMBL →	-1.588	-1.780	.003	<.001	3	3
LIVER	CDK7 →	-0.668	-1.635	.008	.004	2	4
URINARY_TRACT	STN1 →	-0.887	-1.770	.004	<.001	3	3
URINARY_TRACT	SHC2 →	-1.184	-1.823	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC21 by Vacuolar localization activity — KIDNEY

Explore this box plot interactively →