Vacuolar localization

Across TCGA cell cohorts, RNA activity of the Vacuolar localization pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPP21, ADAMTS10, and SLC8A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPP21 grouped by Vacuolar localization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RPP21 →	+0.473	+0.234	.003	.002	3	4
CNS	ADAMTS10 →	+0.279	+0.203	.002	.002	3	3
LUNG_NSCLC_LUAD	SLC8A2 →	+0.123	+0.119	.004	.003	3	3
LARGE_INTESTINE	DNTT →	+0.210	+0.159	.002	.009	3	3
LUNG_SCLC	ARL3 →	+0.203	+0.317	.004	.003	2	4
SKIN	SH3BP4 →	+0.100	+0.147	.009	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPP21 by Vacuolar localization activity — LARGE_INTESTINE

Explore this box plot interactively →