Adaptive thermogenesis

Across TCGA cell cohorts, RNA activity of the Adaptive thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPG21, AUNIP, and FAM210A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adaptive thermogenesis activity versus SPG21 in BONE (Pearson r = -0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SPG21 →	-0.827	-0.341	<.001	<.001	3	4
BLOOD_Leukemia	AUNIP →	+0.715	+0.211	.002	.001	3	4
PANCREAS	FAM210A →	-1.022	-0.208	.003	.003	3	4
SOFT_TISSUE	MOCOS →	-1.682	-0.333	.003	.005	3	4
KIDNEY	RAD9A →	-1.161	-0.209	.002	.003	3	4
LIVER	FEM1B →	+0.759	+0.284	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990845 vs SPG21 — BONE

Explore this scatter interactively →