Response to lectin

Across TCGA cell cohorts, RNA activity of the Response to lectin pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAT3, GINM1, and LAMP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to lectin activity versus ADAT3 in PANCREAS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ADAT3 →	+0.639	+0.783	.001	.001	3	5
STOMACH	GINM1 →	-1.440	-1.485	.002	<.001	3	5
LARGE_INTESTINE	LAMP2 →	-0.558	-0.723	.008	.004	3	5
STOMACH	DYSF →	-1.501	-0.879	.009	.009	3	5
BREAST	APOL6 →	-2.330	-1.026	<.001	<.001	3	4
SOFT_TISSUE	PSMB9 →	-3.526	-1.612	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990840 vs ADAT3 — PANCREAS

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