Dorsal root ganglion development

Across TCGA cell cohorts, RNA activity of the Dorsal root ganglion development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7D3, GEMIN6, and LY6K, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP7D3 grouped by Dorsal root ganglion development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MAP7D3 →	-1.726	-1.114	<.001	.001	3	6
LUNG_NSCLC_LUAD	GEMIN6 →	-0.443	-0.745	.008	.002	3	5
LUNG_NSCLC_LUAD	LY6K →	-2.986	-1.153	<.001	<.001	3	5
BONE	OAS1 →	+3.362	+1.880	.001	<.001	3	4
LIVER	HPRT1 →	-1.320	-1.745	.006	.005	2	5
LARGE_INTESTINE	KCNQ1 →	+2.436	+0.818	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP7D3 by Dorsal root ganglion development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →