Presynaptic active zone organization

Across TCGA patient cohorts, RNA activity of the Presynaptic active zone organization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD4, ACSL5, and TMEM131_S1649, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynaptic active zone organization activity versus CD4 in BRCA (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD4 →	-0.392	-0.052	<.001	<.001	3	5
COAD	ACSL5 →	-0.543	-0.036	<.001	.001	3	4
LUAD	TMEM131_S1649 →	-0.387	-0.066	<.001	.001	3	4
COAD	TMEM192 →	-0.242	-0.038	.002	<.001	3	4
LUAD	CUL4A_S10 →	-0.628	-0.056	<.001	<.001	3	4
COAD	CXCL14 →	-0.818	-0.032	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990709 vs CD4 — BRCA

Explore this scatter interactively →