Presynaptic active zone organization

Across TCGA cell cohorts, RNA activity of the Presynaptic active zone organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAST, SLC4A7, and CAPG, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynaptic active zone organization activity versus CAST in LUNG_SCLC (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CAST →	+1.318	+1.132	.006	.003	3	7
SOFT_TISSUE	SLC4A7 →	+1.031	+1.326	.003	<.001	3	4
SOFT_TISSUE	CAPG →	+5.220	+1.288	<.001	.001	3	4
BLOOD_Lymphoma	RAB40B →	-2.648	-1.522	<.001	.004	3	4
LUNG_NSCLC_LUAD	RASSF5 →	+1.502	+0.736	.001	.007	3	4
OVARY	SMURF2 →	+2.253	+1.789	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990709 vs CAST — LUNG_SCLC

Explore this scatter interactively →