Nucleolar chromatin organization

Across TCGA patient cohorts, RNA activity of the Nucleolar chromatin organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, USP1_S327, and GTF3C2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleolar chromatin organization activity versus SMC2 in UCEC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC2 →	+0.615	+0.068	<.001	<.001	3	8
HNSC	USP1_S327 →	+0.989	+0.078	<.001	.001	3	8
LSCC	GTF3C2 →	+0.288	+0.048	<.001	<.001	3	8
LSCC	NUP155 →	+0.154	+0.038	<.001	<.001	3	8
LSCC	PDCD11 →	+0.419	+0.046	<.001	<.001	3	8
LSCC	DDX56 →	+0.373	+0.046	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990700 vs SMC2 — UCEC

Explore this scatter interactively →