Nucleolar chromatin organization

Across TCGA patient cohorts, RNA activity of the Nucleolar chromatin organization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPFIA2, IGFBP7, and PA2G4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleolar chromatin organization activity versus PPFIA2 in BRCA (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPFIA2 →	-0.227	-0.649	.005	<.001	3	5
BRCA	IGFBP7 →	-0.815	-0.914	<.001	<.001	3	5
LSCC	PA2G4 →	+0.456	+0.755	<.001	<.001	3	5
LSCC	ALOX5AP →	-0.770	-0.899	<.001	<.001	3	5
BRCA	MEDAG →	-1.096	-0.605	<.001	.007	3	4
BRCA	CPQ →	-0.650	-0.955	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990700 vs PPFIA2 — BRCA

Explore this scatter interactively →