Potassium ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Potassium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL2RA, AZI2, and LINC02084, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Potassium ion import across plasma membrane activity versus IL2RA in PDAC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IL2RA →	-0.564	-0.611	<.001	.001	3	4
LUAD	AZI2 →	-0.207	-0.570	.003	<.001	3	4
PDAC	LINC02084 →	-0.355	-0.612	.002	.005	3	4
LUAD	PAX5 →	-0.377	-0.573	.008	.003	3	4
GBM	CALM1 →	+0.512	+0.703	.001	<.001	3	4
CCRCC	BEX4 →	+0.513	+0.388	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990573 vs IL2RA — PDAC

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