Mitochondrial ATP transmembrane transport

Across TCGA patient cohorts, RNA activity of the Mitochondrial ATP transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A4, EPB41L2, and FXR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial ATP transmembrane transport activity versus SLC25A4 in BRCA (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC25A4 →	+0.747	+0.149	<.001	<.001	3	6
BRCA	EPB41L2 →	-0.490	-0.101	.001	<.001	3	4
UCEC	FXR1 →	-0.456	-0.119	.001	<.001	3	4
GBM	QKI →	-0.551	-0.139	.006	<.001	3	4
CCRCC	DNAJB11 →	-0.418	-0.120	<.001	.002	3	4
LUAD	ITGB1-DT →	-0.405	-0.068	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990544 vs SLC25A4 — BRCA

Explore this scatter interactively →