Mitochondrial ATP transmembrane transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial ATP transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALE, EFCAB14, and SLC38A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GALE grouped by Mitochondrial ATP transmembrane transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GALE →	-1.259	-1.131	.001	.002	3	6
BLOOD_Leukemia	EFCAB14 →	-0.587	-1.072	.005	.005	3	5
SOFT_TISSUE	SLC38A2 →	-1.833	-1.604	<.001	<.001	3	5
LUNG_SCLC	TRAF3IP2 →	+2.155	+1.271	.006	.004	3	5
STOMACH	DPP9 →	-0.678	-1.116	<.001	.003	3	4
OESOPHAGUS	GTF2H1 →	-0.972	-1.243	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GALE by Mitochondrial ATP transmembrane transport activity — CNS

Explore this box plot interactively →