Mitochondrial transmembrane transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS11, PPM1G, and AOX1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHRS11 grouped by Mitochondrial transmembrane transport-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DHRS11 →	+0.723	+0.782	.003	.006	2	5
BLOOD_Leukemia	PPM1G →	+0.634	+0.982	.002	.001	3	3
BREAST	AOX1 →	-2.007	-0.977	.001	<.001	3	3
LUNG_SCLC	GPR39 →	-1.647	-0.963	.007	.009	3	3
OESOPHAGUS	CCT7 →	+0.846	+0.982	<.001	.002	3	3
BLOOD_Leukemia	DCAF7 →	+0.494	+0.687	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHRS11 by Mitochondrial transmembrane transport activity — CNS

Explore this box plot interactively →