Mitochondrial transmembrane transport

Across TCGA cell cohorts, RNA activity of the Mitochondrial transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, CPT1A, and TMEFF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial transmembrane transport activity versus TGFBI in LUNG_SCLC (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TGFBI →	+1.397	+0.227	.001	<.001	3	6
LUNG_SCLC	CPT1A →	+1.370	+0.171	.006	.009	3	5
LUNG_SCLC	TMEFF1 →	-1.640	-0.245	.003	.003	3	5
OVARY	SLC16A10 →	-1.191	-0.207	.004	<.001	3	5
PANCREAS	AHNAK2 →	+1.574	+0.300	.006	.005	2	6
SOFT_TISSUE	CHI3L1 →	+1.053	+0.222	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990542 vs TGFBI — LUNG_SCLC

Explore this scatter interactively →