Neuron projection maintenance

Across TCGA patient cohorts, RNA activity of the Neuron projection maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S937, MAP1A_S1776, and RILPL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection maintenance activity versus MAP1B_S937 in PDAC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MAP1B_S937 →	+0.401	+0.050	<.001	<.001	3	7
LSCC	MAP1A_S1776 →	+0.467	+0.037	<.001	<.001	3	6
HNSC	RILPL1 →	+0.252	+0.063	<.001	.003	3	5
LSCC	MAP1B →	+0.553	+0.029	.002	.007	3	5
LSCC	MAP1B_S1400 →	+0.755	+0.038	.005	.008	3	5
HNSC	MAP1B_S1520 →	+0.517	+0.101	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990535 vs MAP1B_S937 — PDAC

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