Neuron projection maintenance

Across TCGA patient cohorts, RNA activity of the Neuron projection maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCCHC24, MAP1A, and ARHGEF25, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection maintenance activity versus ZCCHC24 in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZCCHC24 →	+0.773	+0.600	.003	.007	2	9
LSCC	MAP1A →	+1.077	+1.059	<.001	<.001	3	8
BRCA	ARHGEF25 →	+0.532	+0.564	.002	.002	3	8
GBM	NAP1L3 →	+0.715	+0.372	.001	.001	3	8
OV	THY1 →	+0.754	+0.410	.008	.009	2	9
CCRCC	PODN →	+1.181	+0.845	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990535 vs ZCCHC24 — BRCA

Explore this scatter interactively →