Neuron projection maintenance

Across TCGA patient cohorts, RNA activity of the Neuron projection maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1A, MAP1A_S1776, and MAP1A_S2106, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection maintenance activity versus MAP1A in LSCC (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1A →	+0.801	+1.280	<.001	<.001	3	9
LSCC	MAP1A_S1776 →	+0.768	+1.251	<.001	<.001	3	9
LSCC	MAP1A_S2106 →	+1.128	+1.390	<.001	<.001	3	9
LSCC	MAP1A_S667 →	+0.993	+1.294	<.001	<.001	3	9
OV	NUMBL →	+0.549	+0.792	<.001	<.001	3	9
LSCC	MAP1A_S2022 →	+1.020	+1.198	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990535 vs MAP1A — LSCC

Explore this scatter interactively →