Dense core granule exocytosis

Across TCGA patient cohorts, RNA activity of the Dense core granule exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP1, NUP62, and PRPF40A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dense core granule exocytosis activity versus STXBP1 in GBM (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP1 →	+0.901	+1.219	<.001	<.001	3	4
GBM	NUP62 →	-0.151	-0.613	<.001	<.001	3	4
GBM	PRPF40A →	-0.287	-0.846	<.001	<.001	3	4
GBM	RPL18A →	-0.406	-0.839	.001	.001	3	3
CCRCC	ZNF275_S91 →	-0.989	-1.937	<.001	.001	3	3
CCRCC	C14orf93 →	+1.505	+1.890	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990504 vs STXBP1 — GBM

Explore this scatter interactively →