Dense core granule exocytosis

Across TCGA cell cohorts, RNA activity of the Dense core granule exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A15, ZC3H12C, and ADAM22, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dense core granule exocytosis activity versus SLC25A15 in LUNG_SCLC (Pearson r = -0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC25A15 →	-0.807	-1.222	<.001	<.001	3	4
LUNG_SCLC	ZC3H12C →	+1.392	+1.116	<.001	<.001	3	4
LUNG_SCLC	ADAM22 →	+1.268	+1.158	.002	<.001	3	4
LUNG_SCLC	TXNDC16 →	+1.036	+0.653	.001	.009	3	4
BLOOD_Leukemia	THAP10 →	+0.744	+1.075	.006	<.001	3	4
OVARY	SIAE →	+1.425	+1.289	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990504 vs SLC25A15 — LUNG_SCLC

Explore this scatter interactively →