mRNA pseudouridine synthesis

Across TCGA patient cohorts, RNA activity of the mRNA pseudouridine synthesis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DUT, TBL3, and UTP4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA pseudouridine synthesis activity versus DUT in COAD (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DUT →	+0.379	+0.039	.001	<.001	3	7
HNSC	TBL3 →	+0.215	+0.081	<.001	.001	3	6
HNSC	UTP4 →	+0.293	+0.085	<.001	<.001	3	6
LUAD	GPATCH4_S135 →	+0.737	+0.063	<.001	<.001	3	6
LSCC	UNG →	+0.465	+0.048	<.001	<.001	3	6
LSCC	EMG1 →	+0.292	+0.050	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990481 vs DUT — COAD

Explore this scatter interactively →