mRNA pseudouridine synthesis

Across TCGA patient cohorts, RNA activity of the mRNA pseudouridine synthesis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIN1, MYBL2, and AURKB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA pseudouridine synthesis activity versus GIN1 in LUAD (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GIN1 →	-0.339	-0.155	<.001	.001	3	5
HNSC	MYBL2 →	+0.977	+0.162	<.001	.009	3	5
HNSC	AURKB →	+1.057	+0.195	<.001	<.001	3	5
LSCC	HROB →	+0.801	+0.209	<.001	<.001	3	5
LUAD	UBE2C →	+0.802	+0.112	.006	.003	3	5
HNSC	KPNA2 →	+0.752	+0.176	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990481 vs GIN1 — LUAD

Explore this scatter interactively →