mRNA pseudouridine synthesis

Across TCGA cell cohorts, RNA activity of the mRNA pseudouridine synthesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPK1, DKC1, and TAF4B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA pseudouridine synthesis activity versus ITPK1 in BLOOD_Lymphoma (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ITPK1 →	-1.271	-0.839	.007	.006	3	5
BONE	DKC1 →	+0.793	+1.186	.004	.008	2	6
BLOOD_Lymphoma	TAF4B →	+0.863	+0.853	.009	.004	3	5
OVARY	ANXA5 →	-1.071	-1.008	.007	.002	3	5
OESOPHAGUS	MPP5 →	-0.835	-1.033	.001	.001	3	5
BONE	ABRAXAS1 →	+1.210	+1.265	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990481 vs ITPK1 — BLOOD_Lymphoma

Explore this scatter interactively →