Mitochondrion-endoplasmic reticulum membrane tethering

Across TCGA patient cohorts, RNA activity of the Mitochondrion-endoplasmic reticulum membrane tethering pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDZD8, CDC42BPB, and DNAL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrion-endoplasmic reticulum membrane tethering activity versus PDZD8 in LUAD (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PDZD8 →	+0.226	+0.038	<.001	<.001	3	6
BRCA	CDC42BPB →	+0.196	+0.024	.002	.005	2	6
LUAD	DNAL1 →	+0.291	+0.054	.001	<.001	3	5
OV	TECPR2 →	+0.259	+0.052	.004	.002	3	5
OV	KRI1_S628 →	-0.661	-0.050	.007	.003	3	5
GBM	PSMB10_S230 →	-0.550	-0.048	.006	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990456 vs PDZD8 — LUAD

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