Mitochondrion-endoplasmic reticulum membrane tethering

Across TCGA patient cohorts, RNA activity of the Mitochondrion-endoplasmic reticulum membrane tethering pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GK5, SP5, and SGMS1-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrion-endoplasmic reticulum membrane tethering activity versus GK5 in LSCC (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GK5 →	-0.422	-0.274	.006	.006	3	3
UCEC	SP5 →	+2.150	+0.570	<.001	<.001	3	3
UCEC	SGMS1-AS1 →	+0.522	+0.586	.001	<.001	3	3
UCEC	PREX2 →	-0.854	-0.575	.004	.001	3	3
LUAD	KLHL6 →	-0.510	-0.211	.008	.002	3	3
LUAD	IGLV10-54 →	-1.380	-0.163	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990456 vs GK5 — LSCC

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