Mitochondrion-endoplasmic reticulum membrane tethering

Across TCGA cell cohorts, RNA activity of the Mitochondrion-endoplasmic reticulum membrane tethering pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME3, EBPL, and RGP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrion-endoplasmic reticulum membrane tethering activity versus NME3 in LUNG_NSCLC_LUSC (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NME3 →	-0.992	-0.212	.006	.009	3	4
BREAST	EBPL →	-0.894	-0.161	.005	.008	3	4
LUNG_SCLC	RGP1 →	+1.083	+0.250	<.001	.002	3	4
LUNG_SCLC	ACAT1 →	-1.669	-0.224	.001	.003	3	4
LARGE_INTESTINE	FAM71F1 →	+0.152	+0.234	.006	.003	3	3
LARGE_INTESTINE	MAST4 →	+0.715	+0.180	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990456 vs NME3 — LUNG_NSCLC_LUSC

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