Replication-born double-strand break repair via sister chromatid exchange

pathway activity — cross-omics
GO:1990414Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Replication-born double-strand break repair via sister chromatid exchange pathway is significantly associated with the RNA expression of multiple genes, with the LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RECQL5, TEPSIN, and MSH5, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Replication-born double-strand break repair via sister chromatid exchange activity versus RECQL5 in LUSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUSCRECQL5 →+0.687+0.053<.001<.001324
LUSCTEPSIN →+0.652+0.044<.001<.001324
KIRPMSH5 →+0.748+0.044<.001<.001324
LUSCCHTF18 →+0.859+0.045<.001<.001323
GBMCDK5RAP3 →+0.843+0.046<.001<.001323
LUSCDBF4B →+0.632+0.042<.001<.001323
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990414 vs RECQL5 — LUSC

Per-sample scatter of Replication-born double-strand break repair via sister chromatid exchange activity vs RECQL5 in LUSC.

Explore this scatter interactively →

Exploration