Replication-born double-strand break repair via sister chromatid exchange

Across TCGA patient cohorts, RNA activity of the Replication-born double-strand break repair via sister chromatid exchange pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LACTB, ZNF337, and GEMIN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Replication-born double-strand break repair via sister chromatid exchange activity versus LACTB in COAD (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LACTB →	-0.325	-0.669	.006	.003	3	4
GBM	ZNF337 →	+0.358	+0.591	.007	.002	3	4
GBM	GEMIN4 →	+0.326	+0.758	.007	.001	3	4
GBM	NELFCD →	+0.324	+0.714	.005	.001	3	3
LSCC	TTI1 →	+0.343	+0.189	.003	.001	3	3
LSCC	VWF →	-0.431	-0.159	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990414 vs LACTB — COAD

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